Lupus is a debilitating illness where the body's immune system attacks healthy organs and tissue.
The 25-year-old was first diagnosed in 2015 and had to end her world tour early last year because of panic-related symptoms related to her chronic illness.
The disease affects five million people worldwide but is more prominent in females, according to the Lupus Foundation of America.
Selena's best friend Francia Raisa gave her kidney to the singer whose diagnosis is known to attack areas of the organ and cause inflammation. Photos below
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